In recent years, countries around the world have made great efforts to coordinate energy green and low-carbon development and energy supply. In this context, it is of great significance to build energy stations that can greatly absorb renewable energy. The coordinated operation of multi-energy stations in the region can expand the role of energy stations and strengthen energy complementarity between regions. Aiming at the problem of energy int. In recent years, countries around the world have made great efforts to coordinate energy green and low-carbon development and energy supply. In this context, it is of great significance to build energy stations that can greatly absorb renewable energy. The coordinated operation of multi-energy stations in the region can expand the role of energy stations and strengthen energy complementarity between regions. Aiming at the problem of energy interaction and coordinated operation of multi-energy stations in regional integrated energy system, this paper proposes a two-layer scheduling optimization model, which can effectively reduce the system operation cost and carbon emissions. At the same time, considering the joint demand response, it can effectively reduce the peak power supply pressure of the power grid. In addition, in order to ensure the accuracy and efficiency of the solution, this paper improves the traditional NSGA-II algorithm, greatly improving the overall performance of the algorithm. Finally, the simulation analysis is carried out through an example. The results show that the operation optimization model proposed in this paper can effectively reduce the total energy cost of the system, reduce carbon dioxide emissions, and reduce the peak pressure of the power grid. The coordinated operation optimization method is effective and feasible.••••The proposed joint demand response and dynamic pricing strategies can make the net grid demand curve smoother and have practical significance.••The dynamic pricing strategy helps to realize the joint dispatch of multiple demand response resources in the region and alleviate the grid pressure during peak hours.••A two-layer optimization model is proposed to not only realize the economy of joint operation of multiple energy stations, but also make the net grid demand curve smoother through joint demand response.Regional integrated energy systemOperation optimizationMultiple energy stationsJoint demand response1.1. Literature reviewEnergy is the material basis for human survival. With the emergence of greenhouse effect and the rapid consumption of fossil fuels, it is an inevitable trend to gradually improve the utilization rate of renewable energy. Renewable energy generation has high volatility, so other energy sources need to be configured for coordination. The integrated energy system (IES)can coordinate and optimize the generation, transmission, conversion and distribution of energy, and can effectively realize the cascade utilization and multi-energy complementarity of energy, which has become one of the main directions of energy system development.With the deepening of the energy revolution, the pattern of energy supply and demand has undergone tremendous changes, and the resource types and energy demand scenarios on the demand side have become increasingly complex. It is of great significance to study the application model of demand response(DR) in integrated energy systems.•(1)Research on demand response of integrated energy system1.2. Contribution and article organization structure•1.This paper proposes a dynamic pricing strategy to schedule demand respo. 2.1. System structureThe structure of regional integrated energy system is shown in Fig. 1. Multiple energy stations in the same regional integrated energy system can transmit other information of load demand through communication facilities and share power through energy infrastructure. Because the cold and heat energy in the process of transmission, the network loss is large; and the need to set up pipe network, the investment cost is high, so when considering the multi energy station energy transfer only consider electric energy. Energy station includes the process of energy from production to utilization. The more common energy stations usually include controllable units, such as gas turbine (GT), electric refrigeration (ER), heat pump (HP), electric boiler (EB), gas boiler (GB), combined cooling, heating and power (CCHP), etc., uncontrollable units, such as photovoltaic (PV), wind turbine (WT), and energy storage equipment such as electric storage (ES), thermal storage (TS) and ice storage (IS).From an energy trading point of view, a single energy station can both buy and sell energy.Fig. 1. Regional integrated energy system structure.The multi-energy coupling and coordination between different devices constitute the energy station, and the energy sharing and joint scheduling between the energy stations constitute the regional integrated energy system. Considering the loss and cost of energy tra.